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DiffBiome

Standard or double density human microbiome suspension

in lyophilized form for treating Clostridioides (Clostridium) difficile infections

Move on

Let us fight back infections

with the right composition of microbiome extract

Please select the required treatment time (5 or 10 days) or bacterial density in case of recurrent infection. The usual duration of treatment is 5 days, during which 3 capsules per day are recommended. For patients with severe symptoms, especially those who have repeatedly failed antibiotic therapy, we recommend the use of capsules with double the bacterial density. It is also recommended that all anitibiotic and probiotic administration be discontinued at least 3 days before MTT, as these may neutralise or adversely affect the outcome of the treatment. Double density capsules are specifically recommended for the treatment of recurrent, therapy-resistant cases where avoiding further fluid loss is highly desirable. Usual administration: 2-3 capsules for 5 days, followed by a 3-day break. Keeping a food and complaint diary is not necessary in case of DiffBiome application.

Treating Clostridioides (Clostridium) difficile infections with DiffBiome capsules

Treatment of toxin-producing (A/B or C) Clostridioides (Clostridium) difficile infections is recommended to be carried out by MTT in order to prevent increasing antibiotic resistance and consequent disbiosis. If the patient has a history of laboratory-confirmed infection, a decision on treatment in case of recurrence can be made on the basis of the symptoms. In case of elderly patients, administering double density capsules may be the first choice.

Click on the appropriate button to be redirected to our payment page where you can finalise your order for our services. Once the payment has been received, our staff will contact you by e-mail and send the DiffBiome package of your choice labelled " To the doctor's hand" to the address you provided during the purchase. Please note that although we provide you with the highest quality laboratory certified service, the administration of DiffBiome capsules and the evaluation of the results requires professional experience. Please do not hesitate to contact us if you have any questions!

Complications of microbiome transfer therapy

Most clinical trials and systematic reviews demonstrated that some minor adverse events, like abdominal discomfort, diarrhea, constipation, and low-grade fever, were transiently observed post FMT, whereas uncommon severe side effects were often related to the possible complications of endoscopy and sedation [1], [2].

[1] Wang JW, Kuo CH, Kuo FC, Wang YK, Hsu WH, Yu FJ, Hu HM, Hsu PI, Wang JY, Wu DC. Fecal microbiota transplantation: review and update. Journal of the Formosan Medical Association. 2019 Mar 1;118:S23–S31.

[2] Rossen NG, MacDonald JK, de Vries EM, D'Haens GR, de Vos WM, Zoetendal EG, Ponsioen CY. Fecal microbiota transplantation as novel therapy in gastroenterology: a systematic review. World journal of gastroenterology: WJG. 2015 May 7;21(17):5359.